郭哲杉（博士）。海南省“南海新星”产业创新创业人才（首批）、海南省高层次人才。浙江大学生物医学工程专业博士（2019）；美国明尼苏达大学神经调控中心博士后（2019~2022）；应脉医疗科技（上海）有限公司神经调控部高级科学家（2022）。2022年12月入职小宝影院
，加入殷明教授脑机芯片神经工程团队。
研究方向：
基于脑机接口的在体电生理信息及神经调控，结合影像学、计算机建模等手段，研究神经调控治疗帕金森病、阿尔茨海默症、癫痫、抑郁症等神经系统疾病的神经机制，并开发新型神经调控方法。研究领域涉及神经调控、脑机接口、脑电信号分析与处理、神经系统建模等。
学术论文：
1.Mohanty, B.#, Guo, Z.#, Johnson, L.A., Wang, J. and Vitek, J.L.*, 2025. Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement. Proceedings of the National Academy of Sciences (PNAS), 122(42), p.e2510287122.
2.Yuan, Y., Zhang, J., Wang, C., Yan, H., Ye, X., Ruan, W., Teng, X., Guo, Z.* and Wang, Z.*, 2025. A Transformer‐Based Framework With Data Augmentation for Robust Seizure Detection Across Invasive and Noninvasive Neural Recordings. CNS Neuroscience & Therapeutics, 31(9), p.e70584.
3.Yan, D., Guo, Z.*, Liu, H., Wang, X., Liang, F., Jie, J. and Yin, M., 2025. Comparison of activation and selectivity in dorsal and ventral epidural spinal cord stimulation in rats: a computational modeling study. Scientific Reports, 15(1), p.35711.
4.Panda, P., Bisoy, S.K., Panigrahi, A., Pati, A., Sahu, B., Guo, Z.*, Liu, H. and Jain, P.*, 2025. BIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches. Frontiers in Genetics, 15, p.1491602.
5.Wang Y, Yin M*, and Guo Z*. Circuit-specific gene therapy is knocking on the door of Parkinson’s disease[J]. Zoological Research, 2023, 44(6): 1152.
6.Guo Z, Feng Z*, Wang Y & Wei X. Simulation study of intermittent axonal block and desynchronization effect induced by high-frequency stimulation of electrical pulses[J]. Frontiers in Neuroscience, 2018, 12:858.
7.Guo Z, Feng Z*, Yu Y, et al. Sinusoidal stimulation trains suppress epileptiform spikes induced by 4-AP in the rat hippocampal CA1 region in-vivo[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5817.
8.Zheng L, Feng Z*, Guo Z, Huang L. Simulation Study of Intermittent Responses of Neuronal Populations to Axonal High-Frequency Stimulation[C]. Conf Proc IEEE Eng Med Biol Soc, 2019: 3001-3004.
9.Feng Z*, Guo Z, Wang Z. Advances in Understanding The Mechanisms of Deep Brain Stimulation[J]. Progress in Biochemistry and Biophysics, 2018, 45(12): 1197-1203.
10.Cai Z, Feng Z*, Guo Z, Zhou W, Wang Z & Wei X. Novel stimulation paradigms with temporally-varying parameters to reduce synchronous activity at the onset of high frequency stimulation in rat hippocampus[J]. Frontiers in Neuroscience, 2017, 11:563.
11.Feng Z*, Wang Z, Guo Z, Zhou W, Cai Z & Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction[J]. Brain Research, 2017, 1661:67.
12.Yu Y, Feng Z*, Cao J, Guo Z, Wang Z, Hu N & Wei X. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region[J]. Journal of Integrative Neuroscience, 2016, 15(01):1-17.
13.Wang Z, Feng Z*, Yu Y, Zhu Y & Guo Z. Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5813.
14.Feng Z*, Yu Y, Guo Z, Cao J & Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus[J]. Brain stimulation, 2014, 7(5): 680-689.
主持和参与的部分科研项目：
1. 国家自然科学基金地区项目：基于双向侵入式脑机接口的帕金森病皮层多脑区神经调控机制研究，2026-2029, 24万元，主持
2. 崖州湾科技城“菁英人才”项目：用于帕金森病治疗的新型皮层神经调控技术与设备研究，2025-2027，46万元，主持
3. 海南省科技人才创新项目：基于脑机接口的猕猴帕金森病运动徐缓症状神经机制研究，2024.01-2026.12，50万元，主持
4. 海南省“南海新星”产业创新创业人才平台项目：脑机交互新型手部外骨骼康复机器人，2023-2026，30万元，共同主持
5. 美国国立卫生研究院项目：“Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey”，4R37NS077657-10，2012-2025，67万美元, 参与
6. 美国国立卫生研究院项目：“Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS”（ 5R01NS037019-23），1999-2023，220万美元, 参与
授权专利：
多功能神经电刺激系统控制软件 V1.0. 2015SR110707, 2015. (第二发明人)
招生需求：
招收生物医学工程、数学、电子信息、控制、计算机、自动化、人工智能、神经科学、医学、生物及相关专业的硕士、博士研究生。
联系方式： [email protected]
